Combo of two one-step immunochromatographic tests, the first one for the qualitative detection of GDH (Glutamate Dehydrogenase) and the second one differential qualitative detection of the Toxins A and B, from C.difficile in human faeces
A positive signal in the GDH test indicates the presence of C.difficile in the stool sample. Subsequent analysis of the sample with the test for detecting C.difficile toxins confirms whether the strain is toxigenic and, therefore, pathogenic and disease-causing.
Some of the leading healthcare societies propose the use of a two-step protocol for identifying toxigenic C.difficile involving an initial screening of the sample with a GDH test and, if the result is positive, use of a second test to detect toxins from C.difficile as not all strains of this microorganism produce them.
Operon offers the possibility of following this protocol using its kit GDH+Toxins.
C.difficile infection is considered responsible for approximately 25% of the diarrhoea incidents related to the consumption of antibiotics such as clindamycin, second and third generation cephalosporins, gyrase-Inhibitors, ampicillin or amoxicillin.
In addition to the diarrhoea symptoms, the disease can lead to pseudo-membranous colitis (PMC), requiring urgent treatment with antibiotics effective against C.difficile and which, without treatment, may severely compromise the life of the patient.
|GDH + Toxins||Immunochromatography||stool|
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