Test for the detection of HLA haplotypes associated to celiac disease.
CeliacStrip detects the presence or absence of haplotypes that encode HLA-DQ2 and HLA-DQ8.
Celiac disease is a chronic inflammatory condition of the intestine that is triggered by the consumption of gluten or associated proteins found in wheat, barley and rye. It is one of the most common conditions affecting the Caucasian population, with a prevalence of between 1:100 and 1:500 in Europe and North America.
Susceptibility to gluten sensitivity is to some extent genetically predetermined. In most of the human populations studied, 90-95% of patients were carriers of the heterodimer HLA-DQ2, encoded by alleles DQA1*05 and DQB1*02 in cis position (more common in Central and Northern Europe) or in trans position (more common in Mediterranean countries). The remaining patients (5-10%) often have a second heterodimer, HLA-DQ8 (mainly in indigenous South American patients), encoded by alleles DQA1*03 and DQB1*0302. Patients who are non-carriers of DQ2 or DQ8 may show at least one separate DQ2 allele; very few cases have been described where both alleles are absent.
|CeliacStrip||Hybridization on Strip||ADN|
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